It follows the adventures of a blue-spotted dog named Blue, who communicates with her caretaker by leaving paw print clues around a house inhabited by various talking objects. Due to the succession of the show, foreign versions produced, either dubbing Steve/Joe's voices or replacing them with a completely new host, like in the United Kingdom, Portugal, and Korea, where Kevin Duala, Duarte Gomes, and HyunSup Shin physically appear as their respective country host. There is a Latin American host (though his name is unknown), but no Latin American Blue's Clues episodes surfaced.
The series focuses on Blue, her caretakers Steve and Joe, and the talking objects that take residence at the Blue's Clues house: Mailbox, Mr. Salt, Mrs. Pepper, Paprika, Tickety, Slippery, Shovel, Pail and Sidetable.
Six seasons of the series, consisting of 141 episodes, were produced. In addition to these episodes, a pilot (titled "Blue Prints") and a feature-length movie (titled "Blue's Big Musical Movie") got released.